Action inhibition in Tourette syndrome.
Identifieur interne : 000674 ( Main/Exploration ); précédent : 000673; suivant : 000675Action inhibition in Tourette syndrome.
Auteurs : Christos Ganos [Allemagne] ; Simone Kühn ; Ursula Kahl ; Odette Schunke ; Jan Feldheim ; Christian Gerloff ; Veit Roessner ; Tobias B Umer ; Götz Thomalla ; Patrick Haggard ; Alexander MünchauSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Oxygen.
- pathology : Tourette Syndrome.
- physiopathology : Motor Cortex, Tourette Syndrome.
- Adult, Female, Humans, Image Processing, Computer-Assisted, Inhibition (Psychology), Magnetic Resonance Imaging, Male, Severity of Illness Index, Statistics as Topic, Young Adult.
Abstract
Tourette syndrome is a neuropsychiatric disorder characterized by tics. Tic generation is often linked to dysfunction of inhibitory brain networks. Some previous behavioral studies found deficiencies in inhibitory motor control in Tourette syndrome, but others suggested normal or even better-than-normal performance. Furthermore, neural correlates of action inhibition in these patients are poorly understood. We performed event-related functional magnetic resonance imaging during a stop-signal reaction-time task in 14 uncomplicated adult Tourette patients and 15 healthy controls. In patients, we correlated activations in stop-signal reaction-time task with their individual motor tic frequency. Task performance was similar in both groups. Activation of dorsal premotor cortex was stronger in the StopSuccess than in the Go condition in healthy controls. This pattern was reversed in Tourette patients. A significant positive correlation was present between motor tic frequency and activations in the supplementary motor area during StopSuccess versus Go in patients. Inhibitory brain networks differ between healthy controls and Tourette patients. In the latter the supplementary motor area is probably a key relay of inhibitory processes mediating both suppression of tics and inhibition of voluntary action.
DOI: 10.1002/mds.25944
PubMed: 24995958
Affiliations:
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Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, United Kingdom; Department of Paediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, United Kingdom; Department of Paediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Kuhn, Simone" sort="Kuhn, Simone" uniqKey="Kuhn S" first="Simone" last="Kühn">Simone Kühn</name></author><author><name sortKey="Kahl, Ursula" sort="Kahl, Ursula" uniqKey="Kahl U" first="Ursula" last="Kahl">Ursula Kahl</name></author><author><name sortKey="Schunke, Odette" sort="Schunke, Odette" uniqKey="Schunke O" first="Odette" last="Schunke">Odette Schunke</name></author><author><name sortKey="Feldheim, Jan" sort="Feldheim, Jan" uniqKey="Feldheim J" first="Jan" last="Feldheim">Jan Feldheim</name></author><author><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name></author><author><name sortKey="Roessner, Veit" sort="Roessner, Veit" uniqKey="Roessner V" first="Veit" last="Roessner">Veit Roessner</name></author><author><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name></author><author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name></author><author><name sortKey="Haggard, Patrick" sort="Haggard, Patrick" uniqKey="Haggard P" first="Patrick" last="Haggard">Patrick Haggard</name></author><author><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Inhibition (Psychology)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Motor Cortex (physiopathology)</term><term>Oxygen (blood)</term><term>Severity of Illness Index</term><term>Statistics as Topic</term><term>Tourette Syndrome (pathology)</term><term>Tourette Syndrome (physiopathology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Inhibition (Psychology)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Severity of Illness Index</term><term>Statistics as Topic</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tourette syndrome is a neuropsychiatric disorder characterized by tics. Tic generation is often linked to dysfunction of inhibitory brain networks. Some previous behavioral studies found deficiencies in inhibitory motor control in Tourette syndrome, but others suggested normal or even better-than-normal performance. Furthermore, neural correlates of action inhibition in these patients are poorly understood. We performed event-related functional magnetic resonance imaging during a stop-signal reaction-time task in 14 uncomplicated adult Tourette patients and 15 healthy controls. In patients, we correlated activations in stop-signal reaction-time task with their individual motor tic frequency. Task performance was similar in both groups. Activation of dorsal premotor cortex was stronger in the StopSuccess than in the Go condition in healthy controls. This pattern was reversed in Tourette patients. A significant positive correlation was present between motor tic frequency and activations in the supplementary motor area during StopSuccess versus Go in patients. Inhibitory brain networks differ between healthy controls and Tourette patients. In the latter the supplementary motor area is probably a key relay of inhibitory processes mediating both suppression of tics and inhibition of voluntary action.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name><name sortKey="Feldheim, Jan" sort="Feldheim, Jan" uniqKey="Feldheim J" first="Jan" last="Feldheim">Jan Feldheim</name><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name><name sortKey="Haggard, Patrick" sort="Haggard, Patrick" uniqKey="Haggard P" first="Patrick" last="Haggard">Patrick Haggard</name><name sortKey="Kahl, Ursula" sort="Kahl, Ursula" uniqKey="Kahl U" first="Ursula" last="Kahl">Ursula Kahl</name><name sortKey="Kuhn, Simone" sort="Kuhn, Simone" uniqKey="Kuhn S" first="Simone" last="Kühn">Simone Kühn</name><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name><name sortKey="Roessner, Veit" sort="Roessner, Veit" uniqKey="Roessner V" first="Veit" last="Roessner">Veit Roessner</name><name sortKey="Schunke, Odette" sort="Schunke, Odette" uniqKey="Schunke O" first="Odette" last="Schunke">Odette Schunke</name><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Ganos, Christos" sort="Ganos, Christos" uniqKey="Ganos C" first="Christos" last="Ganos">Christos Ganos</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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